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Milos Filipović

 

 

Department Chemie und Pharmazie
 Lehrstuhl für Bioanorganische Chemie
Prof. Dr. Ivana Ivanović-Burmazović

 

Adresse:

Milos Filipović PhD, wiss. Mitarbeiter (post doc) 

Friedrich-Alexander-Universität Erlangen-Nürnberg
Department für Chemie und Pharmazie
Lehrstuhl für Bioanorganische Chemie
Egerlandstr. 1, 91058 Erlangen, Germany

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Fax:

A 2.45       (Büro)
A 2.18       (Labor)

+49 (0)9131 - 85 27391       (Büro)
+49 (0)9131 - 85 27358       (Labor)

+49 (0)9131 - 8527345
E-mail:
 milos.filipovic@chemie.uni-erlangen.de

 

Doktorarbeit Interactions of SOD mimic with nitric oxide and peroxynitrite: in vitro, ex vivo and in vivo study
Forschungsschwerpunkt:

Nitric oxide biochemistry; Generation of nitroxyl (HNO) and its physiological role; Metal-catalyzed redox modulation of NO signaling; Biochemistry of hydrogen sulfide (H2S) as a signaling molecule; H2S promoted redox modulation od cellular signaling
Veröffentlichungen:
  1. Filipović MR, Stanic D, Raicevic S, Spasic M & Niketic V (2007): Consequences of MnSOD interactions with •NO: •NO dismutation, peroxynitrite and H2O2 generation, Free Rad Res 41, 62-72.
  2. Liu GF, Filipović MR, Heinemann FW & Ivanović-Burmazović I (2007) Seven-coordinate iron and manganese complexes with acyclic and rigid pentadentate chelates and their superoxide dismutase activity, Inorg Chem. 46, 8825-8835
  3. Gao-Feng Liu, Milos R. Filipović Ivana Ivanović-Burmazović, Florian Beuerle, Patrick Witte, Andreas Hirsch (2008): High Catalytic Activity of Dendritic C60 Monoadducts in Metal-Free Superoxide Dismutation. Angewandte Chemie International Edition 47, 21,3991-3994
  4. Filipović MR, Duerr K, Mojovic M, Simovic V, Zimmerman R, Niketic V, Ivanović-Burmazović I (2008): NO Dismutase Activity of Seven-Coordinate Manganese(II) Pentaazamacrocyclic Complexes. Angewandte Chemie International Edition, 47, 8735-8739.
  5. Filipović MR, Koh ACW, Arbautlt S, Niketic V, Debus A, Schleicher U, Bogdan C, Guille M, Lemaître F, Amatore C, Ivanović-Burmazović I:Striking Inflammation from Both Sides: Manganese(II) Pentaazamacrocyclic SOD Mimics Act Also as Nitric Oxide Dismutases: A Single-Cell Study. Angewandte Chemie International Edition, (2010) 49, 4228-4232. 
  6. Engel MA, Leffler A, Niedermirtl F, Babes A, Zimmermann K, Filipović MR, Izydorczyk I, Eberhardt M, Kichko TI, Mueller-Tribbensee SM, Khalil M, Siklosi N, Nau C, Ivanović- Burmazović I, Neuhuber WL, Becker C, Neurath MF, Reeh PW, 2011: TRPA1 and substance P Mediate Colitis in Mice. Gastroenterology, 141(4), 1346-1358  
  7. Filipović MR, Milijković J, Allgaeuer A, Chaurio R, Shubina T, Herrmann M,  Ivanović- Burmazović I, Biochemical insight into physiological effects of H2S: reaction with peroxynitrite and formation of a new nitric oxide donor, sulfinyl nitrite. Biochem. J. 2011 in press,  doi:10.1042/BJ20111389
  8. Ivanović-Burmazović I and Filipović MR: Reactivity of manganese superoxide dismutase mimetics toward superoxide and nitric oxide: selectivity vs. cross-reactivity.   Adv. Inorg. Chem.,  2011, in press.
  9. Filipović MR and Ivanović-Burmazović I: The kinetics and character of the intermediates formed in the reaction between sodium nitroprusside and hydrogen sulfide need further clarification.   Chem. Eur. J., 2012, accepted

 
Vorträge / Poster:
  • Invited lecture, NO, CO and H­2S: from pollutants to mediators of tomorrow, University of Belgrade, Serbian Chemical Society, April 12, 2010.
  • Invited lecture, Novel, physiologically relevant reactions of H2S, University of Bordeaux I, Institute for Molecular Science, May 21, 2010.
  • Invited oral presentation, New way to strike inflamation from both sides: SOD mimics as NO dismutase. An amperometric study. XII Colloque du GFB, Lacanau, France, May 17-20, 2010.
  • Oral presentation at Gordon Conference on Oxygen Radicals, Catalytic Removal of H2S by Water-Soluble Porphyrins as a Model for Heme-Containing Proteins, Ventura, CA, USA, February 7-12, 2010.
  • Selected oral presentation, A new way to strike inflammation from both sides: superoxide dismutase mimics as nitric oxide dismutases, Society for Free Radical Research – Europe: Annual Meeting, Rome, Italy, 26-29 August, 2009.
  • Oral presentation on SFFR-Europe’s Annual Meeting, Ascorbate and nitrite react in human erythrocytes to give a novel product Asc2NO, Vilamoura, Portugal, October 10-13, 2007.
  • Invited lecture at the Department of Inorganic Chemistry, title: Could MnSOD play a role as NO dismutase, University of Erlangen, 29-30 March, 2006.
  • Selected oral presentation on 62nd Harden conference/EMBO workshop, Identification of the reaction product of ascorbate and nitrite as a potential repository of NO in vivo, Cirencester 4-8 April, 2006.
  • Selected oral presentation at Young Investigator award session on the Joint meeting of the German Society of Physiology and the federation of European physiological societies, 26-29 March, 2006.
  • Young Physiologist Symposium and Free Radical School, Birmingham and De Vere, Belfry, oral presentation, 8-10 July, 2005.
  • SFRR-Europe Annual Meeting, De Vere, Belfry, oral presentation, 9-10 July, 2005.

 

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