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Milos Filipović

 

 

Department of Chemistry and Pharmacy Chair of  Bioinorganic Chemistry
Prof. Dr. Ivana Ivanović-Burmazović

 

Address:

Milos Filipović PhD, habilitand (which is equal to assistant professor)

Friedrich-Alexander-Universität Erlangen-Nürnberg
Department of Chemistry and Pharmacy
Chair of Bioinorganic Chemistry
Egerlandstr. 1, 91058 Erlangen, Germany

Room:


Phone:


Fax:

A 2.45       (Office)
A 2.18       (Lab)

+49 (0)9131 - 85 27391       (Office)
+49 (0)9131 - 85 27358       (Lab)

+49 (0)9131 - 8527345
E-mail:
 milos.filipovic@chemie.uni-erlangen.de

 

PhD-Thesis: Interactions of SOD mimic with nitric oxide and peroxynitrite: in vitro, ex vivo and in vivo study
Research:

Nitric oxide biochemistry; Generation of nitroxyl (HNO) and its physiological role; Metal-catalyzed redox modulation of NO signaling; Biochemistry of hydrogen sulfide (H2S) as a signaling molecule; H2S promoted redox modulation od cellular signaling
Publications:
  1. Filipović MR, Stanic D, Raicevic S, Spasic M & Niketic V (2007): Consequences of MnSOD interactions with •NO: •NO dismutation, peroxynitrite and H2O2 generation, Free Rad Res 41, 62-72.
  2. Liu GF, Filipović MR, Heinemann FW & Ivanović-Burmazović I (2007) Seven-coordinate iron and manganese complexes with acyclic and rigid pentadentate chelates and their superoxide dismutase activity, Inorg Chem. 46, 8825-8835
  3. Gao-Feng Liu, Milos R. Filipović Ivana Ivanović-Burmazović, Florian Beuerle, Patrick Witte, Andreas Hirsch (2008): High Catalytic Activity of Dendritic C60 Monoadducts in Metal-Free Superoxide Dismutation. Angewandte Chemie International Edition 47, 21,3991-3994
  4. Filipović MR, Duerr K, Mojovic M, Simovic V, Zimmerman R, Niketic V, Ivanović-Burmazović I (2008): NO Dismutase Activity of Seven-Coordinate Manganese(II) Pentaazamacrocyclic Complexes. Angewandte Chemie International Edition, 47, 8735-8739.
  5. Filipović MR, Koh ACW, Arbautlt S, Niketic V, Debus A, Schleicher U, Bogdan C, Guille M, Lemaître F, Amatore C, Ivanović-Burmazović I:Striking Inflammation from Both Sides: Manganese(II) Pentaazamacrocyclic SOD Mimics Act Also as Nitric Oxide Dismutases: A Single-Cell Study. Angewandte Chemie International Edition, (2010) 49, 4228-4232. 
  6. Engel MA, Leffler A, Niedermirtl F, Babes A, Zimmermann K, Filipović MR, Izydorczyk I, Eberhardt M, Kichko TI, Mueller-Tribbensee SM, Khalil M, Siklosi N, Nau C, Ivanović- Burmazović I, Neuhuber WL, Becker C, Neurath MF, Reeh PW, 2011: TRPA1 and substance P Mediate Colitis in Mice. Gastroenterology, 141(4), 1346-1358  
  7. Filipović MR, Milijković J, Allgaeuer A, Chaurio R, Shubina T, Herrmann M,  Ivanović- Burmazović I, Biochemical insight into physiological effects of H2S: reaction with peroxynitrite and formation of a new nitric oxide donor, sulfinyl nitrite. Biochem. J., 441(2), 609-621 (2012)  
  8. Ivanović-Burmazović I and Filipović MR: Reactivity of manganese superoxide dismutase mimetics toward superoxide and nitric oxide: selectivity vs. cross-reactivity.   Adv. Inorg. Chem.,  64, 53–95 (2012)
  9. Filipović MR and Ivanović-Burmazović I: The kinetics and character of the intermediates formed in the reaction between sodium nitroprusside and hydrogen sulfide need further clarification.   Chem. Eur. J., 2012, accepted
  10. Milos R. Filipovic, Jan Miljkovic, Thomas Nauser, Maksim Royzen, Katharina Klos, Tatyana E Shubina, Willem Hendrik Koppenol, Stephen J. Lippard, and Ivana Ivanovic-Burmazovic (2012): Chemical Characterization of the Smallest S-nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-nitrosothiols, Journal of American Chemical Society. DOI: 10.1021/ja3009693
  11. Mirjam J. Eberhardt, Milos R. Filipovic, Andreas Leffler, Jeanne de la Roche, Katrin Kistner, Michael J. Fischer, Thomas Fleming, Katharina Zimmermann, Ivana Ivanovic-Burmazovic, Peter P. Nawroth, Angelika Bierhaus, Peter W. Reeh, Susanne K. Sauer (2012): Methylglyoxal activates nociceptors through TRPA1 - a possible mechanism of metabolic neuropathies, Journal of Biological Chemistry, DOI: 10.1074/jbc.M111.328674
  12. Otasevic V., Korac A., Vucetic M., Macanovic B., Garalejic E., Ivanović-Burmazović I., Filipovic M., Buzadzic B., Stancic A., Jankovic A., Velickovic K., Golic I., Markelic M., Korac B. (2012): Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility?, Antioxid Redox Signal. DOI: 10.1089/ars.2012.4684
  13. Zimmermann R, Krüger J, Filipovic MR, Ivanovic-Burmazovic I, Calatzis A, Weiss DR, Eckstein R. (2013) A detailed examination of platelet function inhibition by nitric oxide in platelet-rich plasma and whole blood. Clinical Laboratory  (accepted). IF: 0.9
  14.  Filipovic MR*, Eberhardt M, Prokopovic V, Mijuskovic A, Orescanin Dusic O, Reeh P, Ivanovic-Burmazovic I. (2013) Beyond H2S and NO interplay: hydrogen sulfide and nitroprusside react directly to give nitroxyl (HNO). A new pharmacological source of HNO, Journal of Medicinal Chemistry, 56,1499–1508. IF: 5.2
  15.  Babes A, Engel M, Filipovic MR, Fischer MJM, Reeh PW (2013) The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential ankyrin 1 (TRPA1) ion channel, European J Pharamcol. 704, 15-22. IF: 2.73
Invited lectures and oral presentations:
  • Invited talk: "Cellular Cross-talk of H2S and NO", Gordon Research Conference: Thiol-Based Redox Regulation & Signaling, July 29 - August 3, 2012
  • Hot topic talk: "Chemical insight into physiological effects of hydrogen sulfide: Reaction with ONOO- and formation of a new NO donor", Gordon Research Conference: Nitric Oxide, February 13-18, 2011
  • Invited talk: “Chemical insight into physiological effects of H2S”, Max-Plank Institute for Bioinorganic Chemistry, Muelheim, Germany, February 8, 2011
  • Keynote lecture: Redox modulation of NO signaling by MnSOD mimics: A new challenge for therapeutic approaches, International Symposium: 100 years of Ivan Djaja’s Belgrade School of physiology: September 10-14, 2010
  • Invited lecture, NO, CO and H­2S: from pollutants to mediators of tomorrow, University of Belgrade, Serbian Chemical Society, April 12, 2010.
  • Invited lecture, Novel, physiologically relevant reactions of H2S, University of Bordeaux I, Institute for Molecular Science, May 21, 2010.
  • Invited oral presentation, New way to strike inflamation from both sides: SOD mimics as NO dismutase. An amperometric study. XII Colloque du GFB, Lacanau, France, May 17-20, 2010.
  • Oral presentation at Gordon Conference on Oxygen Radicals, Catalytic Removal of H2S by Water-Soluble Porphyrins as a Model for Heme-Containing Proteins, Ventura, CA, USA, February 7-12, 2010.
  • Selected oral presentation, A new way to strike inflammation from both sides: superoxide dismutase mimics as nitric oxide dismutases, Society for Free Radical Research – Europe: Annual Meeting, Rome, Italy, 26-29 August, 2009.
  • Oral presentation on SFFR-Europe’s Annual Meeting, Ascorbate and nitrite react in human erythrocytes to give a novel product Asc2NO, Vilamoura, Portugal, October 10-13, 2007.
  • Invited lecture at the Department of Inorganic Chemistry, title: Could MnSOD play a role as NO dismutase, University of Erlangen, 29-30 March, 2006.
  • Selected oral presentation on 62nd Harden conference/EMBO workshop, Identification of the reaction product of ascorbate and nitrite as a potential repository of NO in vivo, Cirencester 4-8 April, 2006.
  • Selected oral presentation at Young Investigator award session on the Joint meeting of the German Society of Physiology and the federation of European physiological societies, 26-29 March, 2006.
  • Young Physiologist Symposium and Free Radical School, Birmingham and De Vere, Belfry, oral presentation, 8-10 July, 2005.
  • SFRR-Europe Annual Meeting, De Vere, Belfry, oral presentation, 9-10 July, 2005.

 

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